Kimiyyar Turai tana ba da gagarumin haɓaka ga nazarin kiba da zuciya da tallafin Yuro miliyan 10 daga Hukumar Binciken Turai (ERC) don ADIPOhealth, aikin da Cibiyar Nazarin Ciwon daji ta Spain (CNIO) ta daidaita. Ƙudurin yana nufin fahimta, tare da bayanai kuma ba tare da gajerun hanyoyi ba, yadda adipose tissue ke daidaita lafiyar kwayoyin halitta kuma, musamman, tsarin zuciya da jijiyoyin jini.
Bayan nauyin nauyi akan sikelin, binciken zai mayar da hankali kan "inganci" da kuma aikin maiA cewar ƙungiyar da mai binciken CNIO Guadalupe Sabio ya daidaita, dacewar asibiti a bayyane yake: Ɗaya daga cikin mutane biyar a Spain yana fama da kiba. Kuma hadarin da ke tattare da shi ya dogara ba kawai akan yawan kitsen da ke akwai ba, amma akan ko wannan kitsen yana aiki da kyau a matsayin sashin jiki na endocrin.
Tallafin aikin da iyaka
ADIPOhealth shine a hadin gwiwar kasa da kasa na shekaru shida wanda ERC Synergy Grant ya samu, kira mai gasa sosai: Ayyuka 66 da aka zaɓa daga shawarwari 712 daga kasashen Turai 26 da kuma Amurka. A cikin haɗin gwiwar, ƙungiyar CNIO za ta karɓi kusan 3 miliyan kudin Tarayyar Turai don nazarin yadda kitse ke sadarwa da sauran jiki.
Wannan tsarin Haɗin kai yana neman haɗa ƙungiyoyi daga fannoni daban-daban da ƙasashe don amsa tambayoyin da Ba za a iya magance su daban ba.A wannan yanayin, burin da aka raba shine warware siginar da adipocytes ke fitarwa da kuma yadda waɗannan sigina Suna shafar zuciya da sauran kyallen takarda..
Me ya sa "ingancin" mai al'amura
Adipose tissue yana aiki azaman a endocrine sashin jikiYana sakin kwayoyin halitta a cikin jini wanda ke daidaita metabolism na wasu gabobin. Lokacin da wannan tsarin ke cikin sauti, sigina na taimakawa kula da homeostasis; lokacin da mai ba ya aiki, Yana iya haifar da cututtukan zuciya da ciwon daji.
Haɗin kai tare da ilimin zuciya yana da mahimmanci. Baya ga tasirin kiba ga gazawar zuciya. Magungunan antitumor na iya ƙara haɗari kuma an yi kiyasin cewa wani muhimmin sashi na watsi da jiyya a ilimin ciwon daji yana faruwa ne saboda matsalolin zuciya. Fahimtar yadda kitse ke sarrafa aikin zuciya Zai sauƙaƙa daidaita magunguna da ƙa'idodin ga masu kiba ko masu kiba.
Wani mahimmin al'amari na aikin shine sake gyara haɗarin haɗari: masu bincike suna so su bambanta Wadanne masu kiba ne ke cikin hadarin zuciya da jijiyoyin jini? saboda rashin aiki na adipose da kuma waɗanne ne, har ma da ƙarin mai, suna kiyaye wannan haɗarin ƙasa. Akwai ma mutane masu sirara da adipocytes marasa aiki.Lokacin da adipocyte bai adana mai da kyau ba, kitsen yana ƙaura zuwa hanta kuma yana inganta hanta mai kitse kuma, a cikin dogon lokaci, ciwon hanta.
Abin da za a bincika da kuma yadda
Shirin aikin yana farawa tare da ganowa canjin kwayoyin halitta a cikin kitse mara aiki da kuma yadda waɗannan canje-canje ke canza sadarwa tsakanin adipocytes da zuciya. fifiko shine samun biomarkers samuwa a cikin jini wanda ke bayyana cututtukan adipose nama kuma suna aiki azaman maƙasudin warkewa mai araha.
- Ganowa masu zagayawa biomarkers wanda ke nuna ko adipose nama yana aiki daidai.
- Tabbatarwa a cikin samfuran dabbobi da samfuran ɗan adam don ayyana maɓalli maɓalli akan wanda zai shiga tsakani.
- Zane na jiyya da aiki a kan takamaiman hari na adipocyte don kare zuciya.
- Cin gaban nanoparticles don yin daidai da miyagun ƙwayoyi zuwa nama da aka yi niyya.
Wanene ya shiga
Haɗin kai ya faɗi Guadalupe Sabio, shugaban Ƙungiyar Sadarwar Metabolic a CNIO. Daga Spain, za a jagoranci halayyar rashin aikin adipocyte da kuma hulɗar ta tare da zuciya, haɗa bayanai daga. samfurin dabba da samfuran mutum.
- Jesper Olsen ne adam wata (Jami'ar Copenhagen, Denmark): ci-gaba da bincike na proteomic na samfurori don taswirar siginar mai.
- Dale Abel (Jami'ar California, Los Angeles, Amurka): kimantawa na waɗanne kwayoyin halitta shafi ƙwayoyin zuciya da sauran kyallen takarda, da kuma waɗanne ne ke zama masu amfani da kwayoyin halitta.
- Mauro Giacca (King's College London, United Kingdom): zane na nanoparticles mai iya jigilar magunguna da kai zuciya ta hanyar da aka yi niyya.
Tasirin asibiti da ake tsammani
Idan an yi nasarar gano masu gano kwayoyin halitta, asibitin zai samu kayan aikin don bincikar "cutar adipose tissue"Wani abu da ba a halin yanzu a cikin daidaitaccen tsari. Wannan zai ba da izini keɓance haɗarin cututtukan zuciya na zuciya, ba da fifikon shiga tsakani da daidaita maganin cutar kansa a cikin mutanen da ke da kiba.
Ilimin da aka samar kuma zai iya ketare iyakoki na warkewaFahimtar siginar adipocyte na iya samar da sabbin dabarun yaƙi da ciwon sukari, cututtukan zuciya na rayuwa, da wasu ciwace-ciwace, yayin da kuma haɓakawa zuwa ga ƙarin keɓaɓɓen magani.
Tsarin Turai: ERC Synergy da rawar CNIO
da Tallafin ERC Synergy Suna tallafawa ayyukan da ƙungiyoyi biyu zuwa huɗu suka haɗa ƙarfinsu don tunkarar ƙalubalen da ba za a iya magance su daban ba. Wannan tallafin ya faɗi ƙasa Horizon Turai, Shirin R&D na Tarayyar Turai.
El CNIOCibiyar jama'a, a ƙarƙashin Ma'aikatar Kimiyya, Ƙirƙira da Jami'o'i, babbar cibiyar bincike ce ta ciwon daji a Spain da Turai. Tare da kusan ƙwararru 500, aikinsa ya ƙunshi rigakafi, ganewar asali da magani na kansa, da haɗin gwiwar ADIPOhealth ya dace da wannan hangen nesa na fassarar.
Tare da saka hannun jari daga ERC da ƙungiyar da ta haɗu da ilimin halittar jiki na adipose, cardiology, proteomics, da nanotechnology, ADIPOhealth yana nufin fassara "harshen" na mai a cikin gwaje-gwajen bincike da hanyoyin kwantar da hankali waɗanda ke kare zuciya da inganta lafiyar rayuwa a Turai da kuma bayan.
